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 How We Do
Research
by means of science lies at the heart of our efforts to beat the spread of artemisinin tolerance.
Our research, basic and operational,
includes:
· Clinical trials to define the
parasite in falciparum malaria, the geographical
extent of its spread, and to clarify the mechanism of tolerance.
· Daily checks of blood samples until
parasites are cleared, plus occasional re-checks till day 28, and genotyping
of samples.
· Focal screening and treatment, as a
method for actively detecting and treating non-clinical infections by use of atovaquone-proguanil, has replaced an earlier mass
campaign approach in Cambodia,
with the aim to cover 10 infected and 10 control villages by December 2010 in
Pailin.
· Mathematical modeling that takes in
practical issues influential on the spread of tolerance – like the delay in
intervention, the effects of different drugs and intervention strategies, and
the role of behavioural and control approaches.
· Studies to understand vector dynamics
and optimise control in Cambodia, where the environment
is being changed by a sudden surge in deforestation and new patterns of land
use, and to assess the effectiveness of LLINs and LLIHNs,
· New
real-time surveillance mechanisms through electronic exchange of data are
evaluated in Thailand
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